Cayce Health Database
MEDICAL RESEARCH ON THE INTESTINE/PSORIASIS CONNECTION
Edgar Cayce is not alone in recognizing that toxins
leaking from the intestines are involved in psoriasis. The technical
term for leaky intestines is "intestinal permeability." Several researchers
have written on this subject in the medical journals. Here is a
brief summary of that literature.
Humbert, et al. (1991), notes, "A possible relationship
between intestinal structure and function in the pathogenesis of psoriasis
has recently brought about considerable interest." They studied
the intestines of 15 psoriatic patients and 15 healthy subjects and concluded,
"The difference in intestinal permeability between psoriatic
patients and controls could be due to alterations in the small
intestinal epithelium of psoriatics." (p. 324)
Person and Bernhard (1986) note that the pustular
dermatitis associated with small bowel bypass surgery and the
cutaneous manifestations of inflammatory bowel disease are well
known and generally assumed to be due to the absorption
of microbial antigens from the bowel." They hypothesize
that the association of intestinal and dermatological pathology "may be
the result of minor perturbations of mucosal permeability or
the failure of locally produced dimeric
serum IgA to inactivate bacterial or dietary antigens.
Such disparate entities as Reiter's syndrome,
psoriasis, pyoderma gangrenosum, and ankylosing
spondylitis, as well as the pustular
eruptions of Behcet's syndrome, pustular psoriasis,
and lithium therapy, mayshare
this common pathogenesis." (p. 559) This particular research
approach is an excellent example of comorbidity and nonspecificity. In
other words, the same cause may produce a variety of symptoms and syndromes.
Yates, Watkinson, and Kelman (1982) also note comorbidity
and nonspecificity in an article titled, "Further Evidence
for an Association Between Psoriasis, Crohn's Disease, and Ulcerative
Colitis." To test the hypothesis that these three illnesses are
related, they studied 204 patients with inflammatory bowel disease (116
with Crohn's disease and 88 with ulcerative colitis) and 204 age- and
sex-matched controls. Although their research did not directly address
the question of intestinal permeability, they did conclude: "The prevalence
of psoriasis in Crohn's disease (11.2%) and in ulcerative colitis (5.7%)
was significantly greater than in the control group (1.5%). The prevalence
of psoriasis in first-degree relatives of patients with inflammatory bowel
disease was also increased. It is suggested that there is a relationship
between psoriasis, ankylosing spondylitis, sacroiliitis, peripheral arthropathy
and inflammatory bowel disease, which may be explained by common genetic
factors." (p. 323)
REFERENCES AND SELECTED BIBLIOGRAPHY
Barry, R. M., Salmon, P. R. & Read, A. E. (1971).
Small Bowel Mucosal Changes in Psoriasis. Gut, 12(6), p. 495.
Barry, R. E., Salmon, P. R., Read, A. E. & Warin, R. P. (1971).
Mucosal Architecture of the Small Bowel in Cases of Psoriasis. Gut,
12(11), pp. 873-877.
Bedi, T. R., Bhutani, L. K., Kandhari, K. C. & Tandon, B. N.
(1974). Small Bowel in Skin Diseases. Indian Journal of
Medical Research, 62(1), pp. 142-149.
de Vos, R. J., de Boer, W. A. & Haas, F. D. (1995).
Is There a Relationship Between Psoriasis and Coeliac Disease? Journal
of Internal Medicine, 237(1), p. 118.
Fry, L. (1970). The Gut and the Skin. Postgraduate
Medical Journal, 46(541), pp. 664-670.
Humbert, P., Bidet, A., Treffel, P., Drobacheff, C. & Agache, P.
(1991). Intestinal Permeability in Patients with Psoriasis.
Journal of Dermatological Science, 2(4), pp. 324-326.
Madanagopalan, N., Shantha, M., Rao, U. P. & Thambiah, A. S.
(1973). Peroral Jejunal Mucosal Biopsy in Dermatological and
Some Non-diarrhoeal Diseases. Australian Journal of Dermatology,
14(1), pp. 47-52.
Marks, J. & Shuster, S. (1971). Intestinal Malabsorption
and the Skin. Gut, 12(11), pp. 938-947.
Marks, J. & Shuster, S. (1971). Psoriatic Enteropathy.
Archives of Dermatology, 103(6), pp. 676-678.
Moll, J. M., Haslock, I., Macrae, I. F. & Wright, V. (1974).
Associations Between Ankylosing Spondylitis, Psoriatic
Arthritis, Reiter's Disease, the Intestinal Arthropathies, and Behcet's
syndrome. Medicine, 53(5), pp. 343-364.
O'Laughlin, J. C. & Di Giovanni, A. M. (1979). Psoriatic
Enteropathy: Report of Case and Review of Literature. Journal
of the American Osteopathic Association, 79(2), pp. 107-111.
Person, J. R. & Bernhard, J. D. (1986). Autointoxication
Revisited. Journal of the Americal Academy of Dermatology, 15(3),
Salmon, P. R., Read, A. E. & Warin, R. (1969). Radiocarbon
Estimation of Lactose Absorption: A Survey of 104 Patients
with Skin Disease. Gut, 10(12), p. 1052.
Shuster, S. (1968). Dermatogenic Enteropathy. New York
State Journal of Medicine, 68(24), pp. 3160-3165.
Summerly, R. & Giles, C. (1971). Question of Psoriatic
Enteropathy. Archives of Dermatology, 103(6), pp. 678-679.
Yates, V. M., Watkinson, G. & Kelman, A. (1982). Further
Evidence for an Association Between Psoriasis, Crohn's Disease
and Ulcerative Colitis. British Journal of Dermatology, 106(3),
Note: The above information is not intended for self-diagnosis
or self-treatment. Please consult a qualified health care professional
for assistance in applying the information contained in the Cayce Health